All Posts

This blog is based on a recent publication by Dr. Cheryl Wellington 's team at the University of British Columbia in Vancouver, BC, Canada; most of the work was done by Jennifer G. Cooper . The paper is titled "APOE ε4 carrier status modifies plasma p-tau181 concentrations in cognitively healthy super-seniors", see full reference at the end. When biomarkers speak silently. What if the biology of Alzheimer’s disease is present… but the symptoms never arrive? That’s the questi

Overview of nuclei RNA immunoprecipitation. (Good and Ausio, 2025) This blog is based on an article titled “RNA Immunoprecipitation (RIP) from Purified Nuclei in Cells”, published in the book series “Methods in Molecular Biology” in April 2025 by Katrina Good and Juan Ausio. Their work was supported by the Ontario Rett Syndrome Association (ORSA)  grant awarded to Juan Ausio and by an NSERC Alexander Graham Bell Canada Graduate Doctoral Scholarship  awarded to Katrina Good. U

Autism spectrum disorder (ASD) is widely known for challenges in social interaction, communication, and repetitive behaviours. But another dimension of ASD often receives far less attention:  movement . Across decades of research, clinicians and scientists have observed many children with ASD experience difficulty with motor coordination. Yet motor impairments are   not part of the core diagnostic criteria   for autism. This raises an important question: are these motor chall

Pulse wave velocity (PWV) has traditionally been framed as a straightforward marker of arterial stiffness and cardiovascular risk. A higher PWV? Stiffer arteries. End of story. But the story is no longer that simple. Recent work suggests PWV behaves less like a static structural readout and more like a living, breathing reflection of how the cardiovascular system responds to stress. It integrates signals from the heart, blood vessels, nervous system, hormones, and even time o

A Tissue That Never Rests: Life Inside the Intestinal Lining The lining of our intestine is one of the most dynamic tissues in the body. Every few days, it renews itself completely, balancing the need to maintain specialized cell functions while staying flexible enough to repair damage. A recent study reveals that a single epigenetic mark, H3K36 methylation, plays a central role in controlling this balance between identity and regeneration (Meyer et al., 2022). Under healthy

Seeing the Invisible: How New Ultrasound Tools Reveal Early Cardiovascular Risk and Why “metabolic memory” Matters What if we could spot the earliest signs of heart disease long before symptoms appear? Two recent lines of research, one using advanced ultrasound imaging and another exploring hyperglycemic memory , are helping scientists do just that, especially in young people living with type 1 diabetes (T1D). Traditionally, doctors assess cardiovascular risk using blood pres

This story is taken from the paper by Honglin Dong et al. For full details, see below. The aorta is the body’s largest blood vessel, and its strength depends heavily on a special type of cell called vascular smooth muscle cells (VSMCs). In healthy arteries, these cells act like disciplined workers: they contract and relax with every heartbeat, helping the vessel withstand pressure while staying flexible and strong. In aortic aneurysm, however, the vessel wall weakens and expa

Last week on our LinkedIn page, we conducted a daily in-depth analysis of a paper published in January 2026 by Ausio. et al. , in the Biochemistry and Cell Biology journal. Each post examined one step of the method and the underlying chemistry. This blog brings that full journey together: from harvesting cells to purified histones, into one complete story. Why Histones Matter Histones are small, highly basic proteins that package DNA and help regulate the on/off state of the

Here, we select one paper per week and take a closer look, sharing its story with more people! For the daily posts, please visit our LinkedIn page. The first paper we discussed was published in January 2026, titled " Zombosomes are anucleated cell couriers that spread α-synuclein pathology ", by Dakhel, Erlandsson, & collegues. The Day Scientists Met the “Zombosomes” The brain works because its cells are constantly communicating with one another. Among the busiest of these